Microelectrode arrays, electrosynthesis, and the optimization of signaling on an inert, stable surface

• Kendra Drayton-White,
• Siyue Liu,
• Yu-Chia Chang,
• Sakashi Uppal and
• Kevin D. Moeller

Beilstein J. Org. Chem. 2022, 18, 1488–1498, doi:10.3762/bjoc.18.156

• window. The result is an opportunity to measure relative binding constants for ligands for a given receptor. The results presented set the stage for using microelectrode arrays to guide synthetic efforts aimed at probing G-protein/peptide interactions. Natural products YM-254890 and FR-900359. Diblock

Defining the hydrophobic interactions that drive competence stimulating peptide (CSP)-ComD binding in Streptococcus pneumoniae

• Bimal Koirala,
• Robert A. Hillman,
• Erin K. Tiwold,
• Michael A. Bertucci and
• Yftah Tal-Gan

Beilstein J. Org. Chem. 2018, 14, 1769–1777, doi:10.3762/bjoc.14.151

• stimulating peptide (CSP); protein–peptide interactions; quorum sensing; Streptococcus pneumoniae; structure–activity relationships (SAR); Introduction Quorum sensing (QS), a cell-density mechanism utilized by bacteria to assess their population density through the detection of diffusible signal molecules

• interactions and develop novel CSP-based QS modulators with improved activities. When optimizing protein–peptide interactions, it is important to determine which key side-chain residues within the peptide sequence fully occupy their binding pocket within the protein and which ones do not optimally occupy their